Nnianim Nsɛm a Ɛkɔ Akyiri
3,4-Dihydro-2H-pyran (DHP, CAS 110-87-2) yɛ ntamgyinafoɔ ne reagent a ɛsom boɔ kɛseɛ wɔ organic synthesis mu, titire no wɔgye tom sɛ ɛdi dwuma sɛ adeɛ a ɛbɔ nsa ho ban. Sɛ́ ether a ɛwɔ afã asia a enni saturated cyclic ether no, DHP yɛ tetrahydropyranyl (THP) ethers bere a ɛne nsa di dwuma wɔ acid tebea horow mu no. Saa ahobanbɔ kwan yi ho hia wɔ anammɔn pii a wɔde yɛ nneɛma mu de siw nneyɛe a wɔmpɛ ano wɔ hydroxyl mmeae bere a wɔma ɛne mfitiase ne nucleophilic reagents hyia no.
DHP yɛ nsuo a enni kɔla, ɛnnɔɔw pii a ɛnam hydrogenation a ɛyɛ dihydropyran anaa furfural a wɔtumi yɛ foforɔ so na ɛyɛ. Ne reactive vinyl ether nhyehyɛe ma wotumi paw nsakrae ne nsakrae a wɔahyɛ so wɔ organic molecules mu, na ɛma ɛyɛ nea ɛho hia wɔ nnɛyi synthetic chemistry labs ne nnuruyɛ R&D pipelines mu.
Nneɛma a Wɔde Yɛ Adwuma no Ho Nsɛm
| Aguade no Edin | DHP wɔ organic sythesis mu CAS 110-87-2 |
| CAS NO. | 110-87-2 |
| Nsɛmfua a ɛne ne ho di nsɛ | DHP |
| Molekyul Nsusuwii | C5H8O |
| HS Mmara no | 2932999099 |
| Nneɛma a Wɔde Yɛ Adwuma |  |
Nsɛm a Wɔakyerɛkyerɛ mu
|
Nneɛma |
Susudua |
|
Mmaeɛ |
Nsu a ɛyɛ mmerɛw a enni kɔla |
|
Ahotew (%) . |
Ɛboro anaasɛ ɛne 98.5 yɛ pɛ |
|
Nsuo (%) |
Ennu anaasɛ ɛne 0.25 yɛ pɛ |
|
THP(%) 1.1. |
1.3 a ɛboro so |
| Nneɛma a ɛyɛ den (g/cm3) . | 0.922 |
Dwumadi & Dwumadi Titiriw wɔ Organic Synthesis mu
- THP Ether Formation (Nsã ho Ahobammɔ):
DHP ne nsa titiriw ne nea ɛto so abien yɛ adwuma wɔ acid catalyst (sɛ nhwɛso no, p-TsOH, HCl) anim ma ɛyɛ THP ethers. Eyinom bɔ hydroxyl akuw ho ban fi oxidation, acylation, anaa alkylation ho wɔ anammɔn a edi hɔ no mu.
- Ahobammɔ a Wɔpaw:
Ɛnyɛ den sɛ wɔde acid a ɛnyɛ den (sɛ nhwɛso no, acetic acid a ɛwɔ nsu mu anaa TFA) beyi THP akuw no afi hɔ, na ɛma orthogonality a eye kyɛn so wɔ kuw akwan horow a wɔbɔ ho ban mu.
- Nneɛma a Wɔde Di Dwuma wɔ Molekyule a Ɛyɛ Den a Wɔde Yɛ Nneɛma Mu:
Abɔde mu nneɛma:THP ethers ma ntamgyinafo a ɛyɛ adwuma pii no gyina pintinn.
Peptide ne carbohydrates a ɛwɔ nipadua no mu:Hydroxyl-a ɛwɔ nkyɛn nkɔnsɔnkɔnsɔn ne asikre nsa ho banbɔ a wɔpaw.
API a wɔde yɛ nneɛma:Wɔde di dwuma wɔ nnuru te sɛ erythromycin, steroids, ne alkaloids mu.
- Mfaso a Ɛwɔ Gyinabea:
THP ethers no gyina hɔ pintinn wɔ mfitiase, tew, ne oxidative tebea horow a ɛnyɛ den mu, na ɛma kwan ma wɔyɛ nneɛma te sɛ Grignard a wɔde ka ho, base-hyɛ condensations ho nkuran, ne metal-catalyzed couplings.
Nneɛma a Wɔyɛ
-Kyinhyia Ahobanbɔ Adansedie a Edi Mu
Organic Synthesis a Wɔkamfo Kyerɛ sɛ Wɔde Di Dwuma
Multi-anammɔn ahobammɔ a nsa wɔ abɔde mu nneɛma nyinaa synthesis
THP ethers a wɔhyehyɛ wɔ carbohydrate nnuruyɛ mu
Peptide a wɔyɛ a ɛfa serine, threonine, ne tyrosine ahobammɔ ho
Grignard ne organolithium nnuruyɛ a ɛfa hydroxyl-a ɛwɔ nneɛma a edi kan ho
Nnuru ntamgyinafo synthesis baabi a hydroxyl masking ho hia
Nneɛma a wɔde kyekyere nneɛma
Wobetumi anya: 180 kg drums, 1L anaa 5L glass nkotoku a wɔde bedi dwuma wɔ aduruyɛdan mu
FAQ
Asɛmmisa: Dɛn nti na wɔpɛ DHP sɛ wɔde bɔ nsa ho ban?
A: Ɛyɛ ade wɔ tebea horow a emu nyɛ den mu, ɛma THP ethers gyina yiye wɔ tebea horow a ɛyɛ mfitiase anaa nea ɛnyɛ hwee mu, na ɛnyɛ den sɛ wobeyi afi hɔ bere a wɔpɛ no.
Q: So DHP fata ma automated synthesis adwumayɛ nhyehyɛe?
A: Yiw. Ne suban a wotumi hyɛ ho nkɔm ne nea ɛne ahobammɔ a wɔahyɛ da ayɛ-deprotection protocols hyia no ma ɛyɛ nea eye ma automated ne high-throughput synthesis.
Q: So wobetumi de DHP adi dwuma wɔ scale-up nhyehyɛe ahorow mu?
A: Akyinnye biara nni ho. DHP wɔ hɔ pii na wɔde di dwuma wɔ kilogram-to-ton nsenia mu wɔ nnuruyɛ ne nnuru pa nnwuma mu.
Nsɛm a Wɔakyerɛkyerɛ mu
|
Nneɛma |
Susudua |
|
Mmaeɛ |
Nsu a ɛyɛ mmerɛw a enni kɔla |
|
Ahotew (%) . |
Ɛboro anaasɛ ɛne 98.5 yɛ pɛ |
|
Nsuo (%) |
Ennu anaasɛ ɛne 0.25 yɛ pɛ |
|
THP(%) 1.1. |
1.3 a ɛboro so |
| Nneɛma a ɛyɛ den (g/cm3) . | 0.922 |
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